Unrearranged immunoglobulin lambda variable region is transcribed in kappa-producing myelomas.
نویسندگان
چکیده
منابع مشابه
Unrearranged immunoglobulin variable region genes have a functional promoter.
We have tested whether immunoglobulin light chain variable region genes are capable of directing initiation of transcription without undergoing the DNA rearrangement which creates a complete immunoglobulin gene. Two human Vk genes specifically initiated transcription in vitro at a site which is approximately 30 bases downstream of a TATA box and 20 bases upstream of the initiation codon. A Vk p...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1984
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1984.tb02250.x